So "not enough sources" looks probable. The APASS catalog is heavily biased to the galactic plane (to be fair, there are a lot more stars there), while M101 is about as far from the galactic plane as it is possible to get.
I guess you mean "due to drizzle".
Thanks, it's very helpful to know that error is essentially "give up and stop trying for this image", rather than "keep trying with different parameters".
And yes, drizzle... I really need that setting on my browser for "Are you sure you want to post something after midnight, you know your brain is not really working, right?".