Hi,
Drizzle (including x1) will avoid the artifacts of the interpolation algorithms we have in PixInsight in both OSC and monochrome images. These artifacts include the tendency of the stars to become diamond-shaped and ringing around stars with very small PSF (though in this case it is preferable to use drizzle x2).
Drizzle will always give a resulting master light with a healthier noise distribution: interpolation algorithms tend to displace the noise towards larger scales and blur it in areas with aliasing. In plain sight, without any noise reduction applied, the visual appearance of noise with drizzle will be always more comfortable.
Lastly, drizzle usually works very well from 15-20 subframes and, in most cases, it is preferable to the interpolation artifacts. This is not a fixed or exact number, though. One should always perform an inspection of the resulting master to be sure everything went well.
Best regards,
Vicent.