Imho, if you're inclined to learn and change your habits, it worths.
Pixinsight runs very well on linux, in my small experience runs better than windows, maybe because of better RAM and storage management from the kernel, compared to windows.
Just look around and try to choose the desktop environment (KDE Plasma, Gnome, Cinnamon, Ubuntu Unity) you like the most. If you're unsure, try some of the most popular distros, such Ubuntu, Kubuntu, Linux Mint or Fedora. They provide Live-CDs for you to evaluate the system (obviously they will run slower than "real" systems).
They also provide packages to install alternative desktop environments, so for example, if you've chosen Ubuntu, and later you want to use KDE Plasma, you just need to install the "kubuntu-desktop" package to do the switch without reinstalling (it will take a long time anyway, since it needs to download and replace a big number of packages, but you won't lose your data).
Anyway, you can find some obstacles: mostly with software that could not have an exact alternative for gnu/linux, or that requires you to re-learn again how to be productive. Most of the time, it's nothing impossible if you decide to stay.
Also virtualization (any distro provides Virtualbox) lets you run a full Windows environment in a window, so you can still use your old apps while you're looking for alternatives. Some apps will also run "almost natively" under linux using Wine!
I met bigger obstacles with astronomical capture, auto guiding and mount control software. I couldn't find anything equivalent to apps like Firecapture, IC Capture, Maxim DL (speaking of its CCD control tools), or phd guiding. The few alternatives available are still less convenient than windows counterparts.
I tried to run them in Virtualbox and configure hardware emulation so Virtualbox could manage them, but I found this solution unreliable.
So I still have a small Windows partition on my triple-boot macbook (I keep also OSX because I need it for some apps), that I use mostly to take shots with my TIS DMK21 camera.
Maybe next future these won't be problems any more: there are a lot of project that are moving from windows to linux as its user base grows, but in the meantime we need to find hibrid solutions.