The default thread priority used by all modules is always 'High', *never* 'Time-Critical', on the Windows version of PixInsight. This is true unless you select a maximum priority lower than 'High' (e.g. 'Normal') in Preferences.
Some processes use high-level parallelism that tend to sink a lot of processor resources, even with normal thread priority. Two examples are ImageCalibration and ImageIntegration, and also the next (still unpublished) major revision of StarAlignment. CPU affinity control also tends to aggravate this because it 'captures' specific processor cores, which become unavailable to other processes.
Lowering thread priority and disabling CPU affinity, and/or decreasing the number of processors used by PixInsight, will free more resources for other applications. PixInsight allows you to fine tune parallel processing to adapt it to your specific requirements, but the default configuration tries to maximize performance. PixInsight is a computing intensive application, so this default behavior seems reasonable IMO. I'll consider setting the default thread priority to 'Normal' or even 'Low' in the Windows version, but first I must be completely sure that this won't damage us in terms of competing performance.