Rob,
Thanks for the reply. Yes, all the files are in XISF format. I have noticed a behaviour change with the machine from recent updates, drizzle used to kill the thing, try doing anything else with the box and it was hopeless. Now, however, I can happily multi-task whilst drizzling.
This current run looks like it'll be heading closer to 32 hours to complete (on a much larger 4k x 3k patch of the integrated image). It is taking about 7½ minutes on each frame - the drizzle files are between 7 and 10MB in size and the XISFs having come from raws are 283MB, which is the same as it has always been. I don't see anything on the drizzle setup that would allow me to change memory management and in global preferences the only thing that would have any effect (given my limited knowledge) would be the parallel processing and threads, all of which are checked with thread priority on Time Critical (read from a second instance of PI, I'll check this when the drizzle terminates on the primary instance).
Cheers,
David