Ha - that's exactly the Mac keyboard I am using - with the good ole fashioned wire!
And those keys are not working for me.
See my version of PixInsight in the attached screenshot.
Am running on a powerful iMac which is running El Capitan.
The other ALT commands work OK - viz. ALT-R, ALT-P, ALT-C, ALT-Z etc.
Just ALT-N and ALT-E that do not.
I've checked for any sowtware that might be conflicting but cannot find any clues.
Those keys work ok generally, e.g. in this forum editor those key combinations generate special characters. e.g. ˜´
Perhaps someone else running on a Mac can confirm this behaviour?