Yes. Particularly with DBE (symmetries). The new NSG script will also be a new powerful ally for the normalization of data.
(wide field data in particular can suffer from maladies due to poor normalization results).
You know what I am going to say next... I have public free videos on both of these topics. I can't remember who eschews my work however, so I apologize in advance if you are in that set.
I think several (libraries full of) books have been written on the subject ...
The nice thing about M42 and M45 is that they are both bright, so even in the UK I can usually capture lots of data. I've still only started to explore the processing possibilities. M42 in particular rewards HDR processing, but I've not yet produced a result that really satisfies me.