I agree Sander, a good topic for discussion. I traditionally have done my noise reductions steps in two places. FIrst as I assemble the master frames of Red, Green, Blue, etc I use a CCDStack SIgma Reject and Hot/Cold Pixel Reject and then impute the rejected pixels. I use ACDNR or Grey C at the the end of my image processing. So that is my present evolution but not sure I have any solid science behind it<G>.