Hi Jim,
Thanks for posting! Here are my thoughts: I would expect for the F16M a gain of ~1.5 e-/DN and a Gaussian noise ~7 DN assuming a read noise of ~10 e-. In general, if you see denoising artifacts like these, the cause may be one or more of these setting problems: gain is too low, Gaussian noise is too high, variance scale is too high. Any of these things can (will) cause the script to overestimate noise. If possible, please post fits/xisf of integration, two darks, two biases, and the ImageIntegration log in dropbox and I will investigate further.
Thanks,
Mike