I'm with Mark, i do DBE on individual channels, i tend to see different gradients in different channels from my imaging sites. For NR, i always do that after RGB combine, while the image is still linear. I use MMT on linear image and recently changed my workflow and use TVGDenoise on non-linear images, if needed and with a soft touch. Juan and Warren convinced me that TVGDenoise is the tool to use and they were right on. Takes some practice and T/E, but it is a powerful denoising tool.