ok, i didn't realize you were already using Bayer Drizzle.
generally speaking, drizzle trades noise for spatial resolution. so if you downsize your image after drizzle, you just destroyed the spatial resolution you gained, and it's not clear that the noise in the resampled image will be equivalent to the noise if you had not used drizzle at all. if the noise is higher, then i think the whole drizzle/resample process could be worse than just not using drizzle in the first place.
having said all that, since normal debayering involves interpolation, it could be that the drizzle + downsized image is superior to the non-drizzle image.
i think you'll just have to do some experiments to find out the answer...
rob