My personal experience, is that Drizzle works fine, but as jkmorse and pengsloth says, dither is important. It always is.
Another thing I've noticed: When you upsample your image, before post processing them, you tend to be more critical about your processing. You evaluate previews better, it's easier to control stuff like deringing etc. If you then use a 60-80% downsample as the final step, you'll get better results. Not very scientific, but we humans aren't that scientific, when it comes to aesthetic decisions.
Morten
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