Jason,
Previews are your friend here. Granted because of the nature of TVGDenoise, you won't get a perfect match between your previews and final image, but they will be close enough. I generally create 2-4 previews and clone each one. I select 1-2 previews in areas I don't want to loose detail, and I select 1-2 previews in the background regions, especially where there is subtle contrast between the background and dark nebular regions. I close each preview so I can easily see the before and after. On my DSLR images I get good results with the following
Strength 0.015 -2
Edge Protection 0.02 -2
Start with these and see what happens. If you see the "waxy look", decrease the strength.
I hope this helps,
Wade