Hi Wade,
In my opinion (and I prevent you that I am much more a laboratory worker than a real imager), the answer depends on the types of objects in the image, and on the optical system used.
If the image includes small structures with high chrominance contents, spatial resolution can be nearly as important for the chrominance as it is for the luminance. For example, consider a prime focus image of a galaxy, M101 for example. There are many HII regions that are both very small and very strong in the chrominance. If you don't provide enough spatial resolution for the RGB components, these structures will tend to be desaturated, at least partially.
However, as you say the optical system must be able to yield the required resolution on the range of acquired wavelengths. Indeed this may not happen with many lenses.
if you are going to shoot unbinned, you should just go with RGB
I agree with this. If the individual RGB images are taken unbinned, a synthetic luminance computed from the RGB components is in general preferable.
A synthetic luminance has the important advantage that we can specify the contribution of each RGB component to the luminance, in terms of information contents. This can be done in PixInsight by defining a custom RGB working space (with the RGBWorkingSpace tool).
To generate a synthetic luminance, one can extract the L* component of CIE L*a*b*, or the Y component of CIE XYZ. The CIE XYZ space allows us to work separately on the luminance and the chrominance without altering the linearity of the data. This obviously works equally for one-shot color CCDs and DSLR cameras.
Now let's see what the expert imagers here have to say. I'm ready to stand corrected.