this is the infamous canon banding noise. check the following:
are flat subs well-exposed?
how many bias frames? need something like 200 bias frames to minimize injection of more banding into calibrated subs
similarly with the darks, the more the better as this pattern will be in there as well.
if you still see this, then you can try using Georg's CanonBandingReduction script.
generally this script is used on integrated images, but if your project was a multi-night image and your camera rotation was not the same between nights, it will be impossible to remove the banding as it will appear at odd angles. in this case one strategy is to simply integrate each night's work and run CBR on the sub-integrations, then integrate together each night's work.
another strategy is to use an ImageContainer and a process icon for the CBR script to apply the CBR to each sub exposure. this can be dangerous though as the CBR script can put large-scale banding into the image to the left and right of bright features like M42. there's a "protect from highlights" slider that can help mitigate this. another issue is that there are circumstances where the script parameters are not properly saved into the process icon, so you may need to edit the code of the process icon by hand to make sure that the settings you chose for the strength and highlight protection are truly in the process icon for the CBR script.
if you ended up with the large-scale banding in the integrated frame due to not enough highlight protection, you can actually use the CBR script to remove it again. however you have the same issue with multi-night in that case; even though you have removed the banding from each sub, you'd still have to integrate night by night to get rid of the artifacts caused by CBR.
rob