Normally I calibrate the image, align, stack, crop for clean edges (I dither), use DBE if necessary, background neutralization, and then color calibration. But getting a clear area of background when the entire image is nebula is almost impossible. Then I would do multiple previews, combine using preview aggragator and color calibrate. But this doesn't work for all images, at least not for me when the image is overwhelmed with nebulousity. Then I do as posted above.
-Thanks,