Yeah, I'm sorry to say that I too frequently experience a crash when closing Pixinsight in OS X. It doesn't always happen, but seems to occur more frequently after I've completed memory intensive processes (deconvolution, ATWT, etc.). This has happened on both my MacBook pro and my new Mac Mini (both with plenty of memory). In fact, I've had 20 crashes just since 3/11. This has been reported previously, and since it doesn't really impact anything (saved work remains saved), I've just learned to live with it. I'd be more than happy to upload all of these crash reports if they would help.
John
edited to include OS X version (10.8.3), and one other odd behavior. Using my wireless trackpad, often when I try to select New Preview Mode, the cursor, and action, spontaneously jumps over to Pan Mode. This is with the cursor over the image window ready to select the preview box. Corrective action is just tapping the trackpad several times until I'm allowed to select the preview box. I've only noticed this in RC5.