Just a suggestion :
Could you provide a PI-project with your image and all the processing steps made in history
until just before the problem occurs, if you close the windows ?
Maybe this could be helpful for others.
If the problem occurs only in 64bit Windows and not under 32bit, this could also be related to memory
problems (maybe in the upper range of mem, that is not adressed under 32bit, but with 64bit!!).