Hello Claus
I Just downloaded your image.
As far As I can see, there is a guiding problem with it, (Al bright star are doubled)
If this is a single image, there is not much to be done.
If it is the result of a stacking, the I suggest you first to revise the images and exclude the bad ones.
The image itself is not so noisy.
If you make a luminance mask (extract Lightness) and apply it reversed
and then use atruswavelettransform enabling denoise of layers 1 and 2 with deffault parameters, almost all noise is gone.
Regards
Geert