Thanks, Steve!
So you basically confirm my feeling: doing mostly LRGB/Ha at 1x1 (L,Ha) and 2x2 for RGB, just one series of bias/darks at a single exposure for each binning choice should work. That will be a considerable saving, since currently I take darks for all the exposure range I can use (1,3,5,10,20 min) because I am not sure Nebulosity can handle rescaling as well as PI. As for the number of darks, you suggest the same number as I currently take for preprocessing in Nebulosity, but in PI tutorials they recommend more: in any case, planning a single exposure series with 20 frames is perfectly acceptable.
I assume flats at 1x1 binning should suffice, instead, since resampled flats at 2x2 are readily prepared.
Sorry for such basic level questions, but as you know these are most important issues for correct starting preprocessing flow.
Regards,
Antonio