Well, you may try standard noise reduction techniques but definitely it will be better if you remove them from the image before you debayer them. Since the DefectMap process don't work too well with bayered images (today I'm starting a 3 weeks vacation, so I might rewrite it to handle them) I would encourage you to try the CosmeticCorrection scrip. You may use the same master darks to create the needed "defect map".
If there is no coming back, to recalibrate the data, then, as I said, try ACDNR or wavelets. You may help a lot the process is you build a suitable mask. In this case, I think that if you work over the CIE c channel, you may be able to isolate those noisy pixels. Then, use morphological filters to improve the mask.