Just to be sure, I have created a new master bias and dark - Vicent's tutorial. The last set of lights integrated with no failure of MRS noise evaluation.
I'm not sure of what parameters to apply to pixel rejection other than the defaults, keeping in mind that the average frame is 15 seconds and the total over 2 nights = approx 68 minutes.
Sky gradients are outer suburban, where the MW and bright features are discernable - LMC - Eta Carina - M8 and so on. I have attempted to limit the exposures so that sky glow is not overwhelming, tracking errors are minimized and features and stars are not blown out. So lots of frames - 266 so far. 200mm, f/2.8 (first night), f/3.2 (second night) iso 800.
I can get away with up to 5 minute exposures at times, unguided. An old EM-200B, PEC = +/- 5 arc seconds - tracking appears to be excellent, even unguided.