Hi Charles,
Unless you really need an interactive drawing tool --which we
still don't have in PixInsight--, you really don't need to jump to other application to build a selective mask. If you know the coordinates and dimensions of the region that you want to mask (or unmask), then nothing can beat PixelMath. Here are several examples:
A binary rectangular mask:

A binary circular mask:

A circular mask with a linear radial gradient profile:

A circular mask using a nonlinear radial profile (hyperbolic arc sine in this case):

These are just four simple examples. You can generate really sophisticated masks with PixelMath. If you need to smooth the edges of a binary mask, you can do that very easily with the ATrousWaveletTransform tool: just remove the first one or two wavelet layers.
Hope this helps!