Hi Sander,
In the Windows versions of PixInsight, no standard module is using real-time threads except a few very special cases, which don't affect performance of other processes because only very short threads are involved. The core application for Windows is only using real-time threads for screen renditions and color management transformations associated to processes that are triggered by interactive user actions, for example when the user navigates images.
The Preferences interface says that the maximum thread priority is Time Critical, but unlike previous (old) versions, this only means that a process is able to create real-time threads sporadically, not that this is the default thread priority used by processes.
So if you have lowered the maximum module thread priority setting, please set it again to its default Time Critical value, unless you have a very strong reason to lower it, because otherwise a few processes will run somewhat slower. These include StarAlignment (the star matching algorithm) and ImageIntegration, among a few others. The performance of your machine to run other processes won't be affected adversely because, as I've said, real-time priority will only be used for very specific and short threads.