Hi Mike,
The TIFF format does not support many features and metadata items implemented in PixInsight, including the ability to store image properties, such as display functions (also known as screen transfer functions, or STF). If your image was in linear state when you saved it, other retouching and painting applications, such as LightRoom, won't be able to represent it correctly. This happens, for example, if you enable a STF and save the image as a TIFF file without applying the nonlinear transformation first (with HistogramTransformation, for example).