Which gain was set in the camera?
Are you using calibration frames?
What is your calibration workflow?
Statistics and histogram of your JPG image look strange. In the R and G channel, 70 % of the pixels are clipped (i.e. = zero), in the B channel 63 % are clipped. This has to be avoided absolutely. In an astrophoto, the background (region without objects) shall be in the range of about 0.08 to 0.15. That means: in the histogram, the peak of the background pixels shall have its maximum in this region. The peak shall not be cut sharply at the left side but shall smoothly fall to the origin of the diagram.
I assume that your images are calibrated. If the clipping is already visible in the calibrated images, there is something wrong with your calibration master files or in the calibration workflow.
If the calibrated images are not clipped or if you are not calibrating the images (of course you should), the clipping results when you stretch the image: you are applying a too large 'Shadows' value. The HistogramTransformation is showing you which fraction of the pixels will be clipped with the current 'Shadows' setting, see the grey field (red arrow in the appended screen section): the number of clipped pixels and the percentage of clipped pixels will be indicated. Observe these values before performing the stretch and avoid values > 0.1 % if possible.
Since M42 is a very bright object, 30 min of total integration might last if you don't aim for bringing out faintest nebula surrounding M42.
Bernd