When I compare this MasterBias of a cooled ASI1600MM to a FlatDark of my ASI294MC Pro, it doesn't look unusual to me for a CMOS camera: with my camera, the subframes show a (random) horizontal banding which is averaged out by stacking, leaving a vertical banding in the integration which is the "fixed pattern noise" of the sensor. This fixed pattern noise is contained in the light subframes as well and will be removed by the calibration process.
@Adam, it is quite normal that the data scaleEstimate, locationEstimates, imageWeights, zeroOffsets, rejectedLow and rejectedHigh are stored for each subframe in the FITSHeader of the integration, this is the same with integrations saved in XISF format. I agree that the sigma values used for integration are probably slightly too high - I leave them at the default values (with Winsorized Sigma Clipping low sigma: 4, high sigma: 3). However this is not supposed to be the problem here.
@Jim, I guess your issue is not related to this MasterBias but to your preprocessing workflow. Can you please describe it in detail?
Bernd