I just tried an experiment with DBE with some success. I wonder if I'm cheating. First let me say I'm looking for pretty images rather than "scientific " images.
I have been working on a 6 panel mosaic of the Blue Horse Nebula. There is a lot going on in this area. After I crop an image, I usually run DBE because I have a lot of light pollution to contend with. It was hard to see exactly where the samples should be with all the faint nebulosity present. This is when I hit on my new approach.
I downloaded a wonderful image (borrowed) of the region and cropped it so that it matched my image almost perfectly. I then moved the image to Photoshop and resized it so that it had exactly the same pixel size as my image. I then reloaded my borrowed image and did a DBE. Because the borrowed image was so good, I could very easily see where the DBE sample points should be. Once I had my samples placed, I dragged the process icon to my desktop and closed the "borrowed" image. Finally, I dragged the DBE icon on to my image. The results were very nice.
I'm posting this to see if my use of a "borrowed" image to set up the DBE samples was sort of cheating.