The best way I think to approach this is using the ImageSolver script with Distortion correction turned on, MosaicByCoordinates script and the GradientMergeMosaic tool. They all have documentation available in PI and I would suggest reading that. Your biggest problem will be distorted stars in the corners. If your overlap between images are good I would suggest cropping out any problem areas before actually starting the mosaic building process.
I tried a large mosaic a number of years ago just to get an understanding of the scripts and tools. It was made of 15 panels with 4 different lens sizes, 135, 90, 45 and 20mm. While the imaging quality is not great, I think it showed the power of the these scripts and tools. With good images and care during processing I think you should be able to get a result.
Mike