Thanks, Bernd-
That certainly sounds like a plausible explanation for what I've been fighting and a potential solution. If I've understood it, then I really have no alternative to changing the FITS setting in Format Explorer so that the coordinate origin is mirrored in the new camera's lights, darks and flats. And then redo the BatchPreprocessing, Local Normalization for those, followed by then registering the old c_cc files to the new reference frame with Star Alignment. Although I'm thinking that maybe I could alternatively resave the old camera's c_cc.xisf files as c_cc.fits files after changing the same FITS setting so that the old c_cc files (now FITS files) are mirrored to match the new camera. Then I could re-resave them as .xisf files and restore the FITS setting to the PI standard for future use. Do you think that would work equivalently? It seems those modified old c_cc.xisf files should then register to the new cameras reference files using Star Alignment.
For SB folks, (Juan et al.) it would be nice to have a switch available in the Star Alignment process itself that could, for each image in the list of input files, specify whether it should be left unchanged or mirrored prior to doing running the registration process. If I'm correct, that would be a good long term solution for people trying to process data from different cameras whose images have (0,0) in the LL corner instead of UL corner (i.e., are vertically mirrored with respect to each other). It sounds like this must be a fairly widespread problem for people trying to use data from multiple cameras and Star Alignment should be able to handle it with the input specification by the user for each input file.
FYI, both cameras in this case are from the same manufacturer (FLI ML8300 is the old one, FLI ML16200 is the new one) but I do remember that the images I captured (always with TSX Pro) with the new camera had different mirroring properties and was puzzled about that. If I recall correctly, one camera needed a vertical mirror step with the Geometry process to match TSX sky charts while the other camera did not.
CS/Jeff