Running Windows, with three monitors (28", centre, landscape mode; two 19", each side, portrait mode) allows me to have the console on the LHS screen, multiple process panes on the RHS (especially common ones, Like Histogram, etc.).
This then frees up all of the real estate on the main monitor for views and previews. If I could be bothered, I would add another 28" monitor 'above centre' to allow full size previews, etc (and, whilst I am at it, another two at the side of that one - for email and the PI Forum !!!).
One thing that I have found is that it becomes all too easy to succumb to neck or eye strain as you constantly have to move between screens to see what is actually going on. Worse still, I find that I can never find the mouse pointer - it is always hiding on a screen that I am not looking at!
Hope this helps.