Hi Bill,
Your expression should not change, as it depends only on individual frame statistics, and not frame set statistics.
You might want to try SNRWeight / FWHM^2. It avoids having to find mixing constants which are somewhat frame set variable, and also has a more sound theoretical basis IMO.
Any expression using SNRWeight and FWHM should work well across sets with varying ISO and time. This is a useful property.
Thanks,
Mike