Oh yes of course Harry, it's a nonlinear LRGB. I see this every once in a while- brilliant result in the preview, nothing close to it on the actual image, or the larger preview for that matter. See attached guys with same settings. Preview 1 is smaller than Preview 2. I cropped the galaxy out of a clone and HDRMT does work on the crop. So, it seems to be a size issue (?) and not disparity between the preview and the image.
Well, in the end, I applied HDRMT to a masked crop of the galaxy, then used DynamicAlignment to register it back to the main image, then added the result through a mask with PixelMath. That was a lot of work. I would LOVE to know why this happens and if there is any way around it. Thanks!