Also new to PixInsight, but just finished dealing with some hot pixels similar to what you describe in my trial image set myself.
I had quite a lot of nasty blue/green hot pixels showing up in my final image on the first run through, but was able to take care of them by going back and using cosmetic correction (I hadn't bothered on my first run through). It required a fair bit of experimentation to get the right settings, but once I got the hang of what each of the controls did everything worked. In my case, I have separate subs for each color channel, and applying CC on the individual frames right after calibration worked just fine.
What's the procedure you're using?
Duncan