I think that the answer is: "it depends". In many cases, with non-linear images you won't need to use the local support, specially if the noise amplitude seems to be quite the same across the image. If not, then a simple mask to protect the zones with higher SNR can be enough. I would say that the use of the local support in those images is intented only as an advanced option, pursuing for the best result.
I'm sorry that the settings are not obvious (specially those in the local support section). Please understand that this is a state-of-the-art algorithm, and we are discovering it almost at the same time that you. We tried to give the best default settings, and the most meaningful names from our little experience with it. It is one thing to understand the mathematics behind it, and implement it, and another to put a name and intuitive behavior to all the parameters. We'll definitively be using your feedback to design a better tool in the future. Right now I'm coding again the new tgv based deconvolution tool, and later will begin refining the tgv toolset. So, thank you for your feedback and suggestions, and also for your questions. This shows us where to put our emphasis in the upcoming documentation.