I have an 80GB on my desktop (Windows 7 Ultimate, i7, 8GB).
OS and often-used programs (which includes PI) are on the SSD. User directories and everything else (including my image files) are on the spinner.
It's a fast machine, boots in seconds (not sure how many, don't reboot that much), resumes from sleep nearly instantly, but I don't think there's a direct benefit to PI unless you have the space on the SSD for the images that you're processing.
Have you looked at the hybrid SSDs?