Thanks for all the tips... I really appreciate the input.
Since these posts, I have reprocessed the image using a star mask for processes that are not kind to starts (i.e. HDRWT). This has not yielded much better results. In order to trace this issue back to its root, I simplified the processing of M101 for experimental purposes. This simplified process consisted of the processing of a single uncalibrated frame in order to eliminate any calibration or stacking issues as suspects. The steps I took, were debayer, Masked Stretch and then adjustment of the saturation curve. Using only these three steps, my stars still exhibit the damage I showed in my original post.
So... I am either damaging the stars during capture with inappropriate settings (gain and offset) or I the debayer / masked stretch is the culprit...
More to come as I investigate these remaining items.