Hi Rob,
I've just made some tests on Mac OS X 10.6.2 (Snow Leopard up-to-date). Preview.app can open without problems 8-bit and 16-bit ZIP-compressed TIFF files generated with PixInsight 1.5.9.561. So perhaps this is a problem only with OS X 10.5 (Leopard)?
We indeed use LIBTIFF to implement all TIFF format support in PixInsight. Our use of ZIP compression (deflate algorithm) is also standard (or PS would crash upon trying to open one of our TIFF files --sorry, I couldn't resist!
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).
Regarding endianness, LIBTIFF manages it transparently. Applications that use LIBTIFF see TIFF images in the native host machine endian order, irrespective of the actual order used to write the files.
I don't want to say we're doing things better than Apple by no means, but I think we are doing them at least reasonably well, and following the standards in use. The fact that Snow Leopard can open our TIFF files confirms that IMO.