Looking at Warren's book- he suggested 16-25 darks. There isn't much further explanation of why that number (other than to have 2x the number of lights), but let me offer this.
When doing image integration to create your master dark, the master dark represents the noise (plus bias) at your chosen exposure and temperature. Hot/cold/stuck pixels are going to show up here. They're not likely to change much at all over the course of 25-100 frames. You'll probably catch them just fine. The noise however, you'll want to model that as accurately as possible so you can remove that from your light masters. So, rather than looking at the range, you might try doing an ImageIntegration with different threshholds and see what you get for pixel rejections. Take a look here:
http://www.astrosurf.com/jordigallego/articles.html and go to the section: "Image integration techniques: Increasing SNR and outlier rejection with PixInsight" - There is a good PPTX walkthrough of ImageIntegration techniques that let you tease out what's rejected.
Bottom line, if you find that you get the same rejected pixels from 50 as you do 100 frames, there's no value in doing 100 frames.