As a sanity check, calculate the amount of noise you should expect to see in the background.
For your smaller stack, location = 183 DN, gain = 0.294 e-/DN, combination count = 208.
Standard deviation of noise in the background in DN = sqrt(location / (gain * count)) = 1.7 DN
So noise in the background is only a couple DN. You may not be stretching enough to see the difference in the denoised result.
You may want "more" denoising. But that would remove signal and lower SNR. The script is designed to try to avoid that.
On your larger stack, the script is not working properly due to the large intensity offsets. The result is basically undefined.