Hi,
You say that your data has already been stacked outside of PixInsight - does that mean that yoou no longer have the original Lights?
What about calibration frames - do you have any Biases, Darks or Flats for the session?
Without these, you may struggle - PixInsight would not have any of the source data to use to attack these 'defects' at the pre-processing stage, leaving you having to work much, much harder at the post-processing stage. Judicious use of CloneStamp may help, but will be very labour-intensive and time-consuming if you have problems all over the image.