Thanks Juan, I've been doing more investigation of the problem.
I started with re-installing Pixinsight 1195, with all the latest updates.
My imaging camera is a Starlight Express SXVR-H35, so image dimensions of 4008 x 2672 pixels.
ImageCalibration, and ImageIntegration work fine, but SubFrameSelector is giving problems. If I load binned subs, everything is fine, it will analyse 60+ subs happily. However, un-binned subs cause problems.
A short run (10 to 20) of full res subs usually works fine, but more subs (40 or so) cause "PCL FITS Format Support" errors, "Error reading data buffer from file"
On re-running the same sequence of subs, it will stop on a different file, running a shorter set of subs, including the ones it has problems with causes no problems.
Once the error message is up, it locks everything up, even the mouse, and occasionally the PI window will go transparent, or even the whole screen go black, and I have to do a hard re-boot.
Thinking it was to do with the number of stars detected, (my image are widefield, with 18-20,000 stars detected) I've tried running SubFrameSelector on a sequence of 40 full res darks, but the same happened
ImageRegistration causes similar problems, with the system locking up totally on reading some images, again randomly.
These symptoms are not exactly the same as when it was happening on 1195 before I went back to 1123. Then, the PI screen would grey out and no error messages were seen.
I hope this is of some help
XXX EDIT XXX
I was not correct that ImageIntegration worked, I went to prepare some master control frames from a QSI6120, a stack of 40 binned bias frames was OK, but 40 un binned frames caused the same file read error as above.
XX EDIT 2XXX
I can confirm that this is machine specific, have installed PI on my laptop, there are no problems with the same data causing issues on the original system
Huw