I'm no expert on PI either, but, when you're ready to SAVE AS select file format XISF, then you'll see XISF OPTIONS, from there, I've used the "32-bit IEEE 754 floating point" option. When this happened, I opened my original file and did a SAVE AS and saw my failed files where in "8-BIT unsigned integer". You really can't do much with 8 bit images. I had no idea how my image was saved as 8-bit, but, it was. Once I re-created the files as 32 bit XISF then it worked, no problem.
I hope this helps you find your answer.
Doug