Hi Michael,
Looks like your .drz files don't include valid pixel rejection data, or pixel rejection parameters have not been properly adapted to the data set with ImageIntegration.
median stacking with sigma rejection
This can be the origin of the problem. Maybe it is necessary in other applications, but in PixInsight, with very few and very special exceptions, you should always avoid median combination. You should use average combination and fine tune pixel rejection. See the
documentation for ImageIntegration (now outdated, but still useful) for detailed information.
On the other hand, if you use median combination your .drz files won't include, in general, the necessary pixel rejection data. Bear in mind that median combination performs an
implicit rejection of outlier pixels that cannot be emulated by the drizzle integration process.