Dimitris, if rendered at the same physical size on screen, and if equal SNR is desired, then I believe rule of thumb is (maybe surprisingly) equal total time.
Example, a single frame image and a 2x2 mosaic rendered at the same physical size. Downscaling the mosaic by 2x increases SNR by 2x. Don't need this 2x SNR increase, so expose panes 4x shorter to end up with equal SNR. So as a result total time is equal.
This is theoretical. Problems may be not enough subs for good integration rejection, may be harder to process at full resolution due to lower SNR, and (not sure about this) limiting magnitude may be less (a point source issue).
Thanks,
Mike