I think an important point is how to present the final image. For a final version, I would normally resample to 66 or even 50% for the internet. Working at full resolution has some advantages though. You work a lot more critical with your settings, and it is easier to see what you're doing.
Drizzle is a great tool, but before that, I used to resample my registration reference frame to 200%, and reached pretty similar results after deconvolution.
All in all: Do exactly what you feel looks right. I think most of us started doing all this, because we looked at all those Hubble photos and went uhhh! and ahhh!
![smile :)](http://pixinsight.com/forum/Smileys/default/smile.gif)
The point is that a large majority of the astro photos I see, seems to be made to show the strange aesthetic beauty of our Universe. Even though we feel very scientific while we make them.
Br
Morten