Whenever i do a mosaic I try to get "close" on brightness/constrast/color balance/noise on the individual stacked panels, linear fit is one tool that can help with this. Once the panels are merged, you can fine tune the parameters using masks to get a better match and remove any obvious line where the panels merge.
I agree with Rob, I tend to do DBE on individual channels, as a gradient can vary between color channels. I do this on individual filters from a CCD camera, but as he suggests an OSC can be split, dealt with individually, then recombined.
Mosaics have their unique challenges and get better with experience.
BTW, very nice image, Mr. Pelican can be tough.
Joe