i am working on the same thing.
i found that on narrowband images with the FOV that i have, DBE or ABE on the individual panels did more harm than good. the calculated gradient was false and this led to mismatches in brightness along the edges of the frames. this might not apply to your images if they are RGB or there are just super-awful gradients in them.
as you point out, frame adaptation will only work when registering against other images, not the synthetic field.
one thing that i tried was to register each pane to the synthetic field, then crop them back down - the idea being that i could remove distortions from the individual panes that way. then i made a mosaic out of the re-registered panes in the traditional way, building them up frame by frame with frame adaptation turned on.
however, i found that if i stretched my synthetic star field and applied it as a mask, i could see that the stars in the mosaic did not line up everywhere. i think my mistake was using Projective Transformation when doing the initial registration - despite turning on distortion correction i think i needed the 2d splines to properly undistort the panes.
so then i cheated and registered the built mosaic to the synthetic star field with 2d splines and distortion correction turned on. masking the result showed that the stars all lined up nicely.
3 registrations is bad, but that mosaic was supposed to be a reference for creating the images necessary for GradientsMergeMosaic, so i think it's okay.
so with that mosaic as the reference, i created the 4 images needed for GMM, from the original, unregistered panes. here frame adaptation, 2d splines and distortion correction were turned on in Register/Union - Separate mode. unfortunately i seem to have hit a bug because the 4 images have different sizes. they are all very near the reference mosaic size, but not exactly, and GradientsMergeMosaic does not know what to do.
so i'll probably open another thread about that.
rob