Hi Fabio,
Good question. Bigger images have advantages and drawbacks. Two well known drawbacks are increased memory requirements and slower process execution. Both problems grow, in general, as the total surface in pixels, so they tend to worsen quadratically at least.
One of the advantages is a larger and hence more accurate modeling of the PSF. This can be particularly important for wide field images, and is beneficial for several algorithms and tools, especially for those that perform image restoration and sharpening tasks. For example, if the PSF has to be represented as a 5x5 or 7x7 kernel, then we may have a poor discretization and hence poor/uncontrollable deconvolution results. By upsampling the image, we can use discretizations over 9x9 or 13x13 kernels, which are much more accurate. Upsampling is usually done with the IntegerResample tool in these cases. Note that this not only affects deconvolution, but also wavelet-based sharpening, as in this case we can work with larger, more accurate scaling functions that yield better and more controllable results.