Hi,
I would always work in the highest resolution possible. The "Scale" setting of 2 in Drizzle Integration will double the size of the image. I think your issue is caused by your PC having insufficient CPU power and not enuff RAM. My laptop is an i5 with 8GB RAM and PI seems to "hang" when doing very memory/processor hungry routines like MMT and TGVD etc, but I just wait for the process to complete. There are a few things you can do to speed up PixInsight, like edit "Edit" ---> "Global Preferences" ---> "Directories and Network" and add swap files etc.
When Pre-Processing, I create the master Bias, Darks and Flats and then to save disk space I delete those "RAW" files. The Lights are then processed with the Bias, Darks and Flats to create the final Integration file. Again to save disk space, I then deleted the "Calibrated, Cosmetic, Debayered and Registered" files. Never delete the Masters, Lights and of course your Integrated file.
I hope this helps
Look up
John